The exact causes of functional dyspepsia are still unknown, but evidence suggests that its pathophysiology may involve an altered gut-brain interaction, changes in gut microbiota composition and/or function, altered mucosal immune function, visceral hypersensitivity and abnormal gastrointestinal motility. While functional dyspepsia has no organic explanation on routine investigations, recent evidence indicated local duodenal and systemic changes. 2015 8:e16750.Functional dyspepsia is a common and highly prevalent gastrointestinal disorder defined by upper abdominal symptoms, which can manifest both chronically and in isolated incidents in individuals. Study of Lactic acid bacteria community from raw milk of Iranian one humped camel and evaluation of their probiotic properties. 2019 14:e0217021.ĭavati N, TabatabaeeYazdi F, Zibaee S, Shahidi F, Edalatian MR. Identification of Bacillus species: Implication on the quality of probiotic formulations. 2014 28:1073–1078.Ĭelandroni F, Vacchione A, Cara A, Mazzantini D, Lupetti Aand Ghelardi E. Proteolytic and antimicrobial activity of lactic acid bacteria grown in goat milk. Safety properties and probiotic potential of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquifaciens B-1895. 2019 133:786–794.ĪlGburi A, Volski A, Cugini C, Walsh EM, Chistyakov VA, Mazanko MS, Bren AB, Dicks LMT, Chikindas ML. Isolation and structural characterization of levan produced by probiotic Bacillus tequilensis-GM from Tunisian fermented goat milk. Also, the isolated strain showed high adaptability to the gastrointestinal environment, relatively equal percentages of adhesion properties, and some safety aspects, having the potential to be considered as an appropriate probiotic.īacillus subtilis Goat milk Probiotic properties.Ībid Y, Azabou S, Casillo A, Gharsallah H, Jemil N, Lanzetta R, Attia H, Corsaro MM. Goat milk can be recommended as a source of Bacillus isolates. Concerning its probiotic characteristics assessment, especially tolerance to bile salts and acidic conditions, the Bacillus strain could have the potential to consider as a probiotic. The enterotoxin genes were not detected based on PCR assay. subtilis strain was susceptible to various antibiotics. In vitro tests for this strain showed similar results to other probiotic strains. Then, the confirmed isolate was assessed for in vitro probiotic tests, including hemolysis and lecithinase properties, bile salt, acid, and artificial gastric juice resistance, antioxidant activity, antibiotics susceptibility, enterotoxin genes detection, and attachment capacity to the HT-29 cells.Īmong 11 suspected isolates evaluated, only one isolate was identified as B. The primary purpose of the current study was to evaluate the probiotic characteristics of Bacillus subtilis strains isolated and identified from the goat milk samples.Īfter sampling from 40 goat milk and cultivation, suspected colonies were subjected to biochemical and molecular identification. Some Bacillus strains have recently been identified for food applications and industrial as safe bacteria, which mostly have been recognized as probiotic strains. Species of the Bacillus genus have a long history of use in biotechnology.
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